Testosterone buccal system (Striant): comparison with other routes of administration in hypogonadal males

Michael Wyllie

It has been hypothesised that buccal administration of testosterone (T), by preventing first-pass catabolism by the liver, may be a viable alternative to gels, patches and injectables. This abstract compares the pharmacokinetic/clinical pharmacological profiles of several routes of administration. Two studies were undertaken. In both Striant (30mg testosterone buccal system) was administered twice daily (at circa 08.00 and 22.00). In one 14-day, open label study in 26 hypogonadal males at 4 sites a comparison was made with Androgel (5g containing 50mg T ), daily. In the second in 67 patients at 5 sites the comparison was with Androderm (5mg) and /or Andropatch (5mg) for 7 days.

 

 

Recorded in June 2011 at the 20th WAS World Congress for Sexual Health
Forging the Future: Sexual Health for the 21st Century, Glasgow, UK.  
The World Association Of Sexual Health at
http://www.worldsexology.org

 

Michael Wyllie
Michael Wyllie
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Michael Wyllie

Clin Dev, Plethora Solutions Plc, London,UK

Co-authors: W.W. Dinsmore: Dept of GU Medicine, Royal Victoria, Belfast, UK
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WAS - World Association fro Sexual HealthSociety of Australian SexologiestsAustralian Centre for Sexual HealthashnAOFSCSEPI - Council of Sex Education and Parenthood (International)SASSM